"No country should close its borders or place any restrictions on travel and trade. Such measures are usually implemented out of fear and have no basis in science.
"They push the movement of people and goods to informal border crossings that are not monitored, thus increasing the chances of the spread of disease.
"Most critically, these restrictions can also compromise local economies and negatively affect response operations from a security and logistics perspective."
Africa CDC states it remains highly concerned at the potential spread of the virus to neighbouring Uganda and South Sudan.
Africa CDC director-general Dr Jean Kaseya stated the highest number of cases are concentrated in the remote Mongbwalu area of Ituri province, bordering the Opkapi wildlife reserve.
He added continuing attacks by Islamic State-backed militants are preventing effective surveillance and response operations in the region.
The DRC has undergone 17 Ebola outbreaks since the disease was first reported in the country in 1976.