At the time, Marr was forced to take nine months off work to recover and was cared for by his wife, journalist Jackie Ashley.
One user on X wrote: "That was quite hard to listen to. I don't know what was wrong with him, but he would probably be better off at home resting."
Another said: "I abhor his politics and his far left woke agenda but this is difficult to hear. Sincerely hope he's ok."
A third user noted: "You would have thought his producer might have stepped in at that stage as he's already had a major stroke."
Despite the concerns for Marr's health, after a short break he appeared to get back on track and resumed the rest of the broadcast without any further signs of a problem.
A fourth X user observed: "I heard this live and thought he was dying on air. They then played a pre-recorded piece and he came back fine five mins later and didn't mention a thing."
Marr was formerly the BBC's political editor, joining the corporation in May 2000, before spending 16 years at the helm of his own Sunday morning show. He signed off from the BBC in December 2021 after 21 years.
When he announced he was leaving, he said he was "keen to get my own voice back".
In 2021, it was announced Marr was joining the New Statesman as their political editor. In January 2023, he took on an additional role as Sunday morning host of Classic FM.
Philip Noyce, Classic FM's managing editor, said: "Andrew is an outstanding broadcaster and communicator who shares our vision to present the greatest classical music in a way that anyone and everyone can appreciate."