Engineering and manufacturing firms were hard hit, with Melrose and Rolls-Royce plunging lower once again.
Catalytic converter manufacturer Johnson Matthey sank after it told investors it is cutting 2,500 jobs following a major hit from coronavirus.
The FTSE 100 firm also revealed plans to halve its dividend to shareholders as it announced the redundancies, which will remove more than a sixth of its workforce over the next three years.
Shares in the company dropped by 148p to 2,043p after it revealed it took a £60 million hit to profits from the virus.
British Gas owner Centrica also lost share value after it announced plans to cut 5,000 jobs as part of a major turnaround plan.
More than half of the job losses will come from the business’s leadership roles, as Centrica revealed it would strip out three layers of middle managers, in a bid to cut bureaucracy.
Shares in the company slipped 1.71p lower at 40.12p at the end of trading.
Tui dropped lower after it extended the suspension of holidays for customers from the UK due to coronavirus travel restrictions. Shares fell by 41.7p to 444.6p.
The biggest risers on the FTSE 100 were Polymetal, up 32p at 1,536p, Fresnillo, up 8.8p at 776.2p, LSE, up 28p at 8,094p, and Tesco, up 0.7p at 227.7p.
The biggest fallers of the day were Carnival, down 164.5p at 1,190p, Melrose, down 12.65p at 111.15p, ITV, down 7.72p, and Rolls-Royce, down 31.7p at 321.6p.
