Shu added that there were no immediate plans to find a replacement chief technology officer.
Deliveroo is backed by early Facebook investor Accel Partners and Index Ventures - which is also an investor in rival takeaway service Just Eat - and has raised around $200 million (£144 million) since its inception in 2013.
Investors paid £133.85 for shares in the latest funding round in November, valuing the company, which allows users to order food from restaurants such as Gourmet Burger Kitchen that do not already offer takeaways, at £376 million. Orlowski’s stake in the business is worth £46 million.