"Glazer is not someone we felt comfortable with having a large stake in the club, let alone take it over.
" We are against any takeover bid in principle as if the club goes private it denies fans a chance for a stake in their club. The club's plc stages its AGM on 12 November and it promises to be a heated meeting."
Glazer, who is also the owner of the Tampa Bay Buccaneers American football team, has hired investment bank JP Morgan to act as advisers for the bid.
To succeed, he will need the support of John Magnier and JP McManus, the Irish racing tycoons whose Cubic Expression investment vehicle is United's largest shareholder with a 28.9 per cent stake.
United reported a 29 per cent fall in annual pre-tax profits to £27.9m last week but shares lifted almost four per cent following the announcement. The current price values the club at around £700m.
On the pitch, United have made a disappointing start to the season and sit nine points behind Arsenal in the Premiership.
