Smith ended the day with 196 yards and completed 12 of 19 passes. In contrast, Denver quarterback Kyle Orton completed 28 of 40 passes for 369 yards.
But he was also guilty of two turnovers, when the ball was swatted out of his hand in the fourth quarter, setting up Gore's touchdown run, and then throwing an interception to put the lid on the Halloween game.
There is some concern over there being a fifth consecutive NFL regular season game at Wembley next year, with the League in negotiations with their players' union over a new collective bargaining agreement.
NFL UK managing director Alistair Kirkwood said: "We won't be able to move forward on the International Series until the collective bargaining agreement is reached."