"I just tried to play every match the best I can from the first one. Try not to think too much about the draw, just play match by match," Pennetta said after her win.
"I tried to be focused on what I have to do all the time when I get on the court and here I am, so I'm very happy."
With the crowd still filing into Arthur Ashe Stadium Pennetta grabbed the first break of the match to go up 3-1 and then pulled away from an out-of-sorts Halep.
Halep's problems followed her into the second set as Pennetta broke again to take the early initiative before the feisty Romanian finally began to push back breaking the Italian and surging into a 3-1 lead.
One of the WTA Tour's best counter punchers, Halep tried to go on the attack but a calm Pennetta would not crack and swept through the next three games to regain momentum and a 4-3 advantage.
Serving to stay in the match, Halep fought off one match point before her resistance collapsed, Pennetta finishing off her opponent with stinging forehand winner.