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Murray's consistency against lesser opponents is impressive, with the 28-year-old having reached 17 consecutive grand slam quarter-finals.
He will be confident of avoiding an upset against Seppi too, after winning their last six encounters without even dropping a set.
"I expect a tough match," Murray said. "He made the final in Halle two weeks ago and he beat Roger (Federer) in Australia, so he's a very dangerous opponent."
Murray was left dissatisfied by a battling first-round victory against Mikhail Kukushkin but the world number three showed his class against Robin Haase in round two, ousting the Dutchman with his variety and speed of thought.
A more dominant, aggressive style of play has been high on Murray's agenda this year and crucial to that adjustment has been new coach Jonas Bjorkman.
Bjorkman, who reached a career-high ranking of four in the world, joined Amelie Mauresmo on Murray's backroom team in March and Tim Henman believes the Swede will prove an excellent addition.
"I know Jonas very well, I played 10 years at least on the tour with him, we practised together a lot and he's a great guy," Henman told Press Association Sport.
"I think he will have a very positive impact, and he'll have more and more responsibility with Amelie Mauresmo's pregnancy.
"You talk about someone getting the maximum out of their game, he was limited but he made it to four in the world.
"That depth of analysis and work ethic will definitely translate into making him a good coach and when you've got the tools of Murray's trade as well, to use those in the right fashion, I think it's a great combination."
John Isner, the American who beat Nicolas Mahut 70-68 in the final set of their record-breaking Court 18 duel five years ago, was involved in another marathon five-set contest on Friday that was stopped due to fading light.
Isner and Croatia's current US Open champion Marin Cilic were locked together when play ended for the day, with the score at 7-6 (7/4) 6-7 (6/8) 6-4 6-7 (4/7) 10-10 after four hours and 16 minutes.
Consequently the Court One battle was billed to resume on Saturday afternoon.
