Singletary hopes that travelling 33,264 miles this season, more than any other team in the NFL, will not hamper their progress as they search for only their second NFC West division title in 13 years.
"The trip to London is perfect. It comes at a good time for us. I think the timing is right," he said. "It gives us a chance to get away from whatever is happening at that time. Coming here gives us sort of a mid-season break.
"We're excited about the opportunity to allow our great players to get that exposure, and for the people in London to see an up-and-coming team. Everything happens for a reason. It is a big stage and we'll embrace it."
Last season the Niners won five of six games in their division, yet they finished behind Arizona with an 8-8 record and they'll be looking to raise the bar in 2010.
"The expectation level in San Francisco has always been high," said Singletary. The 51-year-old father of seven was an intense competitor on the field, and was a leader in a Bears' locker room that included eighties gridiron icons William The Refrigerator' Perry and maverick quarterback Jim McMahon.
His motivational gifts and impassioned speeches are legendary. Yet Singletary, who also preaches in church, hopes that he won't have to revert to the visual aid he gave the 49ers in his inaugural game as head coach.
At half-time, trailing the Seattle Seahawks 20-3 at home, Singletary called everyone to attention, dropped his trousers and pointed to his rear end, to fully emphasise what the coach thought of his players' performance.
"I used my pants to illustrate that we were getting our tails whipped and how humiliating that should feel," Singletary said. "I needed to do something to dramatise my point. I think they got the message."
But whatever the outcome at Wembley, Singletary promises one thing: His belt will remain buckled.