Those defeats - 2-1 in the Riazor and 3-2 at Old Trafford - still rankle with Scholes, who scored in the match in Spain. He said: "Over the two games we maybe should have won both.
"In the first we should have been two or three-nil up before they scored. In the second we played well and were unlucky not to win the game.
"All the players are looking forward to it and we know we are capable of doing well."
Manager Sir Alex Ferguson is without Juan Veron (Achilles). Striker Van Nistelrooy returns after being rested against Leeds.