Morgan Williams, the Canada scrum-half, is due back from the World Cup to be on the Saracens bench. Prop Emiliano Bergamaschi will start ahead of Andy Kershaw.
Rod Kafer, the Saracens coach, said: "We have done a bit of soul-searching after the Wasps game. We must show character, pride and determination."
Quins have five players back from injury at Leeds tonight, including hooker Ace Tiatia, outside-centre Chris Bell and winger Ugo Monyeand.
Also tonight, London Irish are at Sale, where Barry Everitt comes in at fly-half for ankle injury victim Mark Mapletoft.