Quins may rest almost permanent choices like South African lock Steve White-Cooper from the Newcastle mission so that he can play in the Cup. It was his try against Northampton which earned the semi-final place.
Saracens director of rugby Francois Pienaar was delighted that tries from Kevin Sorrell, Tim Horan, Tony Diprose and Dan Luger produced a precious bonus point and underlined the problems Quins will face in the Cup because he already rates Leicester as clear favourites in the league.
"We are playing for second place," he said. "It's not in our hands any more. It was a month ago but not any more, that is the sad part of it."
Wasps next take on second-placed Northampton at Franklins Gardens on Saturday having come from behind to beat London Irish 29-16 at Loftus Road.
Wasps trailed for 70 minutes but pulled up to 16-15 when Kenny Logan kicked the last of five penalties. Then, in the last 10 minutes, they added two tries through hooker Trevor Leota and wing Paul Sampson, Logan converting both.
But Wasps director Nigel Melville had no doubts that they will need to raise their game at Northampton.
