The Buffalo Bills, Wembley-bound themselves later this month, played six games in Canada between 2008 and 2013 but fewer than 40,000 spectators attended their last fixture at the Rogers Centre.
Mexico is the only other nation to have staged a regular-season game when the San Francisco 49ers and Arizona Cardinals met in front of 103,467 fans in Mexico City in 2005. A report on NFL.com last week suggested Mexico is one of the countries the league is considering for its International Series expansion.
"This marks an important step in our long-term international growth," NFL commissioner Roger Goodell said of the 10-year commitment.
"Fans in the UK have responded incredibly well to the regular-season games we have played in London since 2007. They have demanded more NFL games, and we have worked to accommodate them.
"We think it's time to expand our International Series to other countries and respond to the growing interest in our game not only in the UK, but elsewhere around the world."
