Fourth seed David Nalbandian crashed to the in-form Radek Stepanek 6-2, 4-6, 6-1, while eighth seed Feliciano Lopez of Spain lost to was also on the wrong end of an upset by falling to Belgian qualifier Olivier Rochus 6-4 7-6 (7/4).
ANDY RODDICK utilised his booming serve to turn back South Korea's Lee Hyung-Taik in the first round of the Kroger St Jude ATP tournament in Memphis.
The American sent down 11 aces as he eased to a 6-3, 6-4 victory in just 58 minutes.
The world number three never faced a break point and broke serve once in each set to defeat the South Korean for the second time in as many tournaments.
Roddick is seeking his second consecutive ATP victory after picking up the San Jose Open title in California last week, an event where he beat Lee on his way to the final.
The American will face Arnaud Clement in the second round after the Frenchman defeated Davide Sanguinetti of Italy 7-6 1-6 6-1.
KIM CLIJSTERS beat Jelena Kostanic of Croatia 6-2, 6-3 in the Diamond Games in Antwerp in her first match in four months.
Former world No. 1 Clijsters said her problematic left wrist, which kept her off the WTA Tour for most of the past year, did not bother her during the opening match in defense of her hometown title.
"So far so good," Clijsters told more than 10,000 home fans in a packed Sports Palace. "I had good backhands, not always perfect ones, but that is to be expected at this point. I hope all will go better now."