Warren Gatland, the Wasps director of rugby, said: "We're looking forward to an atmosphere which we expect to rival the raucous crowd that cheered us on against Leicester in the Premiership two weeks ago.
"It is crucial that we secure a win this weekend and we certainly need all the fan support we can get at home before entering enemy territory."
Leicester coach John Wells is confident three of his England forwards will recover from knocks and play.
Props Graham Rowntree (hamstring), Julian White (shoulder) and No8 Martin Corry (ankle), have been named in the starting line-up.