Reaching this season's Lord's showdown - never mind winning it - already looks a mighty tall order for an outfit that cannot approach the experience levels of either Pakistan or Australia - even when everyone is fit.
Hussain and No1 all-rounder White are not due to play any part in the tournament. Recovering, respectively, from a broken thumb and a dodgy back in time for the Ashes series are their priorities.
But neither seamer Caddick (back) nor senior batsman Thorpe (calf) will be ready to return before Tuesday's match against Pakistan at Lord's at the earliest. A stand-in for Thorpe will be added to the squad today and he could straight into Sunday's meeting with Australia.
However, finding a winning formula is going to be far harder than naming a temporary replacement.
After losing their last two one-dayers in Pakistan before Christmas and then being whitewashed 3-0 in Sri Lanka earlier this year, England pledged to revisit the drawing board.
The emphasis is still on would-be all-rounders, though, and right now the likes of Ben Hollioake, Paul Collingwood, Mark Ealham and Dominic Cork are unable to compete with their opposite numbers in the Pakistani and Australian teams.
Stewart admitted: "We had two huge setbacks in 24 hours. Losing Caddick and Thorpe meant we went out against Pakistan with a very inexperienced side."
Saeed Anwar and Inzamam-ul-Haq have both scored more than 8,000 one-day international runs - twice as many as even Stewart.
Yesterday, the pair put together a stand of 150, effectively winning the game for their side.
But there was still time for an important contribution of 38 from Azhar Mahmood.
Remarkably for someone who is not a household name anywhere in the world, Mahmood has played 103 one-day internationals.
Take away Stewart and Darren Gough and that is almost as many appearances as England's entire team. At least Nick Knight made a welcome return to the side with an undefeated innings of 59.
But there were precious few crumbs of comfort for the hosts at Edgbaston and they may be equally hard to find throughout the next couple of weeks.