His Harlequins counterpart Dean Richards, with five potential starters on international duty and half a dozen injured, had to make another change two hours before kick-off when winger Seb Stegmann dropped out with flu.
But the reshuffle in the backs resulted in Nick Evans switching to full-back from fly-half for his injury-delayed home debut. The move panned our well, with the former All Black contributing 19 points - including a stunning first-half try.
But Richards said: "It wasn't just about him and his finishing. It was the quality of the rugby that led up to it.
"Our scrum dominated their theirs, which must have been disappointing for them.
"The brand of rugby we are playing at the moment gives you an idea of the feeling in the camp."
Gloucester got their title challenge back on track with a 25-21 victory over Saracens, for whom the defeat was the first at home this season, while London Irish beat Newcastle 24-8 at Kingston Park.