Some insiders predict they will wait for their contracts with her to end before looking for a new face to represent their brand.
The police probe into Moss's conduct has been ordered by Assistant Commissioner Tarique Ghaffur, head of the Yard's Specialist Crime Directorate. He wants officers to interview Moss when she returns from New York, where she has been for the city's fashion week. She is expected back for London Fashion Week today.
The 31-year-old model, who has a two-year-old daughter, was captured on video taking cocaine two weeks ago at a studio in West London where her rock star boyfriend Pete Doherty, 26, and his band Babyshambles were recording.
Detectives will also seek to question Doherty and anyone else who was present. Mick Jones, formerly of The Clash, is producing the album which Babyshambles were making.
Last Friday the Metropolitan Police said it would investigate Moss's behaviour 'if a complaint is received'. Since then Yard chiefs are understood to have been stung by criticism that they were not honouring the word of Metropolitan Police Commissioner Sir Ian Blair's last February when he promised to tackle the scourge of middle-class cocaine abuse. Sir Ian said then: 'There are people in the capital who believe that they are in some way taking harm-free cocaine. There are no areas of the capital which are exempt from the law on drugs.'
The aim of the inquiry will be to find out where the drugs came from with a view to arresting the supplier. As such, Moss and her entourage are likely to be treated as 'witnesses'.
Moss is expected in London for the catwalk show of her friend Sadie Frost's label FrostFrench.
Earlier this week friends described how Moss had lesbian sex sessions with Miss Frost and actress Davinia Taylor. The pair are said to be planning to link arms at the show in a gesture of defiance.