The mayor added: "You can do what we did during the Olympics where you have a regime that tries to have specific marshalling points, areas where the big loads are brought in and then dispersed in a more rational and efficient way.
"It's a big technical problem. Internet shopping is creating more traffic and we need to address it."
RAC Foundation director Steve Gooding said: "When it comes to internet deliveries it is no surprise people are receiving goods at work because obviously they are not at home during the day to receive them there.
"The mayor has already recognised this and is helping some firms establish click and collect points at Tube stations.
"Surely the emphasis should be on expanding the number of secure drop off points so we can all benefit from the convenience of internet shopping without adding to city-centre congestion."