Listeners will be able to question the Mayor by phone, text, email or via Twitter while the show will be streamed on the LBC website and on Facebook Live.
LBC’s Managing Editor James Rea said: “With our listeners in the driving seat, LBC has a long history of holding people in power to account and they don’t hold back in tackling the issues that matter to them.
"After Ask Boris, Call Clegg and Phone Farage, our callers will have the opportunity to challenge the new Mayor directly and find out about his plans for London."