Whereas doctors tend to administer it in combination with oxygen — with the nitrous oxide component varying between 50 and 70 per cent — those inhaling gas from canisters and balloons consume it pure. As a result, warns Danny Lee Frost, of the Medicines and Healthcare Products Regulatory Agency, they may risk suffering oxygen deprivation: ‘Hypoxia can occur, which may lead to loss of blood pressure, fainting and even heart attack.’ In February, Jordan Guise, 21, from Worcestershire, died after taking laughing gas while working as a chef in Béziers. French authorities gave the cause of death as asphyxiation through the use of nitrous oxide. Prolonged exposure — for instance, by attempting to make the high last longer by taking repeated hits — can also result in bone marrow depletion and vitamin B deficiency as the nitrous oxide blocks absorption. This can cause nerve damage, leading to tingling and numbness in the fingers, toes and other extremities.