If you've watched the last few weeks of Doctor Who you'll have seen her alter ego, Amy Pond, skitter down frowsty spaceship corridors, across sinister English village greens, around vampire-filled Venetian palazzi and through a forest populated by malignant alien gargoyles. 'The other day I was looking at a version of myself in a new computer game and I asked for the legs to be changed.' They were too muscular, 'almost like a body-builder's', and she asked for them to be made more feminine. See, she's noticed, too.
As we find a space in the palace café to drink tea, it quickly becomes clear that Karen is much more comfortable talking about sex than politics. I ask if she voted in the General Election. 'That's a secret!' she exclaims in the same excitable Scottish tones she uses on TV. 'Isn't it? I don't talk about that sort of stuff.' If Karen thinks that the former Doctor Who, David Tennant, was right to come out for Gordon Brown, and agrees with her boss, Steven Moffat, the programme's new head writer, that the country should be run by anyone but the Tories, then the truth can't yet be told. Being the Doctor's sidekick is clearly more of a diplomatic role than it used to be.
Get her on the precise nature of the relationship between Amy and Matt Smith's freshly regenerated Doctor, however, and some Newsnight-standard comment and analysis gush forth. First we talk about the peculiar but oddly compelling shape of her co-star's head. 'I've never seen anything like it,' she agrees. 'And he has an aura as well. A head and an aura.' Smith is, apparently, as eccentric as he seems. 'He has some strange mannerisms but he really doesn't see it. All those odd things he does with his hands.' She performs an explanatory mime that suggests she may one day find work with outré director Lars von Trier. 'As you spend more time with Matt you don't notice it so much and he becomes normal. And that's how it must be for him. He feels normal. But he isn't. Which is great for the Doctor.'