Shire Pharmaceuticals, up 11p at 590½p, received a boost from broker Smith Barney, which has begun coverage with a buy recommendation and a healthy 725p target. It says the proposed acquisition of TKT is a 'smart strategic shift with substantial potential upside and acceptable risks'. It values TKT at 200p a share and Shire at 564p, assuming a 50% chance of generic competition for Adderall, its treatment for attention deficit hyperactivity disorder, next year.