Royal & Sun Alliance, down 20p at 212 3/4p, led the blue-chip fallers, closely followed by 3i Group which tumbled 39 1/2p to 593p. Aviva suffered a fall of 49p to 413p. Pharmaceuticals were also in the wars, led down by AstraZeneca, off 123p to 2342p, with GlaxoSmithKline 80p lower at 1190p and Shire Pharamceuticals down 20 1/2p to 556p.