Drugs discovery group Phytopharm saw a fifth wiped off its market value after a key client, Japan's Yamanouchi Pharmaceutical, delivered a bodyblow. It is dropping a potentially lucrative licensing agreement for new Alzheimer's treatment Cogane, one of the company's two leading pipeline products. As a result, Phytopharm, down 39p at 150p, is scrapping the planned £24m fund-raising that would have accelerated the development of the Alzheimer's treatment and of motor neurone drug Myogane. Broker Numis cut its recommendation to hold from buy.