Drugs company CeNeS Pharmaceuticals, which is listed on AIM, advanced by 1p to 8.87p on news that Anglo-American giant Glaxo-SmithKline, 2p firmer at 1282p, has bought 13.3 million shares, a 5% stake. City speculators have been left wondering if this could signal a commercial tie-up between the two companies, or even the possibility of GSK making a full bid.