Tokyo Electron, the world's second-largest maker of semiconductor production equipment, gained 220 yen, or 5.2%, to 4410 yen. Takeda Chemicals was among the high-profile losers, the latest victim of fears that it will suffer heavy share sales by Japan's pension funds. The drugs maker sank 170 yen, or 4.2%, to 3840 yen, its lowest standing in five years. The benchmark Nikkei 225 Average extended Tuesday's gains to close up 40.66 points at 7879.49.