Sir Harold won the Nobel Prize for Literature in 2005. In February of that year he announced he was to retire to concentrate on political activism and poetry.
Betrayal is based on an affair Pinter had with broadcaster and writer Joan Bakewell, who was then married to producer and director Michael Bakewell. It was last staged in the West End in 2003.
Michell, who directed a revival of Pinter's Old Times at the Donmar in 2004, has not yet cast the play.
Other highlights at the Donmar this year include the premiere of Michael Frayn's The Crimson Hotel and Tony-winning Broadway musical Parade.