This time their old friend, Banky Edwards (Jason Lee), has sold them out by going to Hollywood to produce a picture for Miramax based on the comic book about their alter egos, Bluntman & Chronic, starring two popular young Hollywood actors, played by Jason Biggs and James Van Der Beek. This sets Jay and Bob off on a mad trip from Jersey to California, to save their 'reputations' and get even with Hollywood.