Introducing the film, she said: "He has been chewed up and spat out many times but one thing people always say is that he is one of the finest actors of his generation.
"I am proud to work with him and to be able to call him a friend." Mel Gibson - who produced and co-starred in The Singing Detective, helped Downey win the role but could not attend the screening. Gibson gave him a Harley Davidson on set for successfully completing a year of rehab.
Other guests at last night included Annie Lennox, actress Meera Syal, model Saffron Aldridge, Sir Trevor Nunn and REM singer Michael Stipe. The Singing Detective will be released across the UK on Friday. Gothika is due in Britain next March.