For all his admiration of literature — the title of the book is paraphrased from a sonnet by Jacobean poet Baron Fulke Greville —Kalanithi chose neurosurgery for its insights into how “biology, literature and philosophy intersect”. Working as a resident surgeon, he witnessed countless injuries and describes performing many operations, the mistakes and failures, as well as the successes, with death never far away. “I had started in this career, in part to pursue death: to grasp it, uncloak it, and see it eye to eye, unblinking.” He worried about his failure to empathise with his patients and their families. What he told them, and how he said it, mattered enormously. Yet he also thrilled at his superlative technical abilities. When he cut “the dark gray rotting tumour” cleanly out of “the fleshy peach convolutions” of the brain he’d mutter “Got you, you fucker”.