Scientists here in the UK had caught a glimpse of life outside the programme, and seen that it is very cold. Aside from the money (researchers have been unable to apply for crucial grants), science is inherently collaborative — and without Horizon’s ties, collaborations between EU and UK scientists started to break down. Then there is the UK’s scientific standing. There are three main science groupings in the world — North America, China, and Europe. Left out, it is hard to be considered a major science nation. “You’re sort of floating out into the cold north-east Atlantic,” as Professor Paul Nurse, a Nobel laureate, has said. Some scientists have left the UK altogether.