Trouble in America took its toll on technical controls and instruments designer Spectris, which was down 15p at 1689p, after revealing a 1% fall in like-for-like sales in the four months ending October.
Lifesciences firm OptiBiotix, whose shares have rocketed close to 300% making it one of the small-cap stars of the year, edged up 0.5p to 78p after signing a deal with Italy’s CSL, which will fund the development of a new product.
The company is working on a range of products to tackle obesity, high cholesterol and diabetes.