"We are well placed to respond to the evolving regulatory environment as well as the short-term challenges of low interest rates," he said.
The Portuguese banker also highlighted the government's efforts to sell off the taxpayers' stake in the bank, which received a £20 billion bailout during the height of the financial crisis.
The Treasury has whittled down the stake from 25% to less than 11%.
Commenting on Chancellor George Osborne's plans to sell £2 billion worth of the bank's shares to the public next year, Horta-Osorio added: "We welcome the further progress that the government has made this year and will fully support the proposed retail offer."